Ответил в английской ветке: https://www.netxms.org/forum/configuration/server-and-agents-are-separated-by-nat/msg25297/#msg25297
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from org.netxms.base import GeoLocation
node = session.findObjectByName("netxms")
print node.getGeolocation()
md = NXCObjectModificationData(node.getObjectId())
md.setGeolocation(GeoLocation(11.0, 22.0))
session.modifyObject(md)